Not always a joy for ever

[Glucocorticoids in rheumatoid arthritis: almost always or hardly ever?].

The use of glucocorticoids in rheumatoid arthritis has been the source of frequent debate in the last decades. There is evidence on its anti-inflammatory capacity and its power to decrease radiologic progression, particularly if used in recent onset rheumatoid arthritis. However, there are still some voices questioning its use. Their arguments are its potential side-effects, especially when the...

Not Always Buried Deep

KLP Not Always Efficient

The size of the nondominated set of a vector set is greatly dependent on the size of the original vector set N and the dimension of the vector M . Theoretical analysis shows that when M = O(log N) the original set has big nondominated set which may be the original set itself, and in the case M = O(log N), a classical algorithm (KLP) for finding nondominated set has complexity of KLP higher than...

For telomeres, longer is not always better.

N E W S " Short people got no reason to live, " goes the Randy Newman song. The same used to be thought of cells with short telomeres, those indispensable nubs of repetitive DNA and protein coating that protect the ends of chromosomes. But if Randy Newman was singing about telomeres, he would have to rewrite his lyrics. New findings are overturning what scientists thought they knew about the im...

Pneumatosis Intestinalis: Not Always a Surgical Indication

We present a case of pneumatosis intestinalis (PI) of the colon in the setting of inflammatory bowel disease that was treated with medical management rather than emergent surgery. While the reflex response to extraluminal air in the abdomen is abdominal exploration, consideration of the clinical context in which PI is discovered and an understanding of a complete differential diagnosis of the s...